isha@iitk.ac.in

Diabetes is one of the most commonly occurring disease and is often accompanied by several disorders like retinopathy, nephropathy, neuropathy etc. According to WHO (2018), forty percent of the American population suffering from diabetes had dysfunctional kidneys i.e. an impaired renal system. So, what begins as a simple hyperglycemia, leads to a perturbed kidney function which if left untreated leads to kidney failure in the patients. My aim is to study the high glucose conditions that create a strain on the filtration system i.e. diabetic nephropathy using Drosophila as a model. The fly components, nephrocytes and Malpighian tubules, are homologous in function to the mammalian kidney in terms of filtration and secretion, making the fly an apt model to study nephropathy. Thus, my goal lies in identifying the key factors and the mechanism involved that cause damage to the fly’s renal system. Even though some factors like ROS are known to perturb the structure and function of a nephron, it still leaves certain questions behind. One such question that I wish to address is the inter-organ communication in case of diabetes. It is interesting to dig out how one organ that is majorly the impacted due to diabetes has consequences on the other and to understand the systemic effects of diabetes.

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