sbanrje@iitk.ac.in

I am interested in understanding the local and systemic changes that take place during lifestyle-induced diabetes and its associated disorders like obesity. Type 1 diabetes, which is an autoimmune disease, mostly occurs in the younger population and can be treated with insulin doses. Type 2 Diabetes (T2D), however, is a lifestyle-induced disease which occurs in older people as a result of high caloric diet, lack of exercises or as a consequence of a variety of other factors. T2D leads to many metabolic diseases like obesity, cardiovascular diseases, retinopathy, to name a few. India has the second highest diabetic population and its prevalence has increased in the younger generation as well. Hence it is a disease of the ‘new age’ which needs to be addressed. I am using Drosophila as a model system to study the diet induced T2D. Drosophila provides an excellent platform to study the inter-organ communication network which is highly perturbed in diabetes. T2D associated insulin resistance is well studied in tissues such as fat body (Drosophila equivalent of adipocytes) and muscles, which are major organs for the glucose uptake. Hence my tissue of interest is fat body and muscles. Further, I would like to study the other nodes and circuitries in insulin signaling and their involvement in the instigation of diabetes. I am also interested in the herbal mitigation of diet induced T2D and the mechanism of action and target nodes of these herbs.  

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